In this paper, I offer both a brief study of Collingwood's conception of historical explanation and epistemological historicity, and an examination of the influence of Collingwood's work on the historical methodology of Quentin Skinner and on Gadamer's hermeneutic philosophy. Collingwood's work on the philosophy of history manifests a tension between the realist implications of the doctrine of reenactment and the logic of question and answer on the one hand, and, on the other, the constructionist tendency of the rest of his (...) work on the logic of historical inquiry and on the hermeneutic character of his more general conception of human historicity. This tension is displayed in the divergent interpretations of Collingwood by Quentin Skinner and Hans-Georg Gadamer, and in the inherent difficulties of each man's philosophy of history. I argue that the weaknesses of Skinner's methodological historicism are present already in his reading of Collingwood and reflect the difficulties inherent in understanding Collingwood as offering primarily a methodology of history. I also claim that Gadamer's hermeneutic philosophy, while presenting a more plausible reading of Collingwood, suffers from tensions similar to those within Collingwood's work between the logic of explanation and the logic of practical recommendation, and between the character of historical explanation and the character of philosophical understanding. (shrink)

This essay consists of an examination of the work of three thinkers who conceive of liberal education primarily in teleological terms, and, implicitly if not explicitly, attempt to offer some answer to the question: what does it mean to be fully human? John Henry Newman, T. S. Eliot, and Josef Pieper developed their understanding of liberal education from their own intellectual and religious experience, which was informed by a specifically Christian conception of the place of education in a fully developed (...) human life. I suggest that the strength of their understanding of liberal education derives from its connection to the various small cohesive religious communities to which they were connected. Nonetheless, this insularity was also the primary weakness because each writer ended universalising what was in fact a particular and unique cultural and religious experience instead of providing convincing proof of a single human nature with a single telos. I will contrast this teleological conception of liberal education with that of Michael Oakeshott and his student Kenneth Minogue, both of whom wrote about education in a post-religious era in which the earlier consensus had completely broken down. They both celebrated the variety of practices which human beings have invented for themselves over the past several centuries (and past several millennia), and did not appear to suffer from the lack of any unifying single human telos. I will suggest that their understanding of practice insulated them from the need for a single unifying telos. (shrink)

This essay consists of an examination of the work of three thinkers who conceive of liberal education primarily in teleological terms, and, implicitly if not explicitly, attempt to offer some answer to the question: what does it mean to be fully human? John Henry Newman, T. S. Eliot, and Josef Pieper developed their understanding of liberal education from their own intellectual and religious experience, which was informed by a specifically Christian conception of the place of education in a fully developed (...) human life. I suggest that the strength of their understanding of liberal education derives from its connection to the various small cohesive religious communities to which they were connected. Nonetheless, this insularity was also the primary weakness because each writer ended universalising what was in fact a particular and unique cultural and religious experience instead of providing convincing proof of a single human nature with a single telos. I will contrast this teleological conception of liberal education with that of Michael Oakeshott and his student Kenneth Minogue, both of whom wrote about education in a post-religious era in which the earlier consensus had completely broken down. They both celebrated the variety of practices which human beings have invented for themselves over the past several centuries (and past several millennia), and did not appear to suffer from the lack of any unifying single human telos. I will suggest that their understanding of practice insulated them from the need for a single unifying telos. (shrink)

Because of the public identification of both Michael Oakeshott and Leo Strauss as conservative political philosophers, there have been numerous comparisons of their political thought. Whatever similarities or differences that do exist between them, it is certainly true that they shared a keen interest in the history of political thought. However, they understood the character of history in widely divergent ways. In the following paper, I examine the way in which each writer understood the logic of historical explanation, and there (...) are two primary reasons for wanting to do so. First, there have been few examinations of either writer’s arguments concerning historical understanding, despite the stature of both as historians of political theory. Second, the differences between Oakeshott and Strauss on history are central to two fundamentally opposed ways of understanding the past, each of which has manifested itself in the contemporary practice of the history of political thought. I will argue that Strauss’s approach to the past is primarily a practical one and yields a concern with a legendary or mythical past constructed primarily to address contemporary political problems, and that his specific methodological propositions are either irrelevant to a specifically historical understanding of the past or inadequately argued and unconvincing. Conversely, I will suggest that Oakeshott offers a coherent and compelling account of the logic of historical understanding, which involves both a defense of the autonomy of historical explanation and an elaboration of the character of historical contextualism. (shrink)

Thomas Jefferson’s argument against long-term debt and his theory of usufruct are used to show why each generation is obligated to protect the independence of future generations. This argument forms the theory of “Jeffersonian generational independence.” The theory has wide implications for the environmental movement because most environmental problems result in limitations on the liberty of future generations. I compare and defend Jeffersonian generational independence from two alternatives including the investment theory raised by James Madison and the problem of generational (...) interdependence raised by John Passmore or Edmund Burke. When the obligation to protect the independence of future generations is taken seriously, liberalism can no longer reasonably be used to defend environmental exploitation, since such exploitation amounts to an attack on the liberty and independence which form its core values. (shrink)

The c‐myc proto‐oncogene is normally subject to complex regulation at the transcriptional and post‐transcriptional levels in proliferating and differentiating cells. It is activated in response to growth stimuli and generally, though not always, repressed in response to differentiation signals. Abnormal, deregulated c‐myc expression is a common feature of numerous malignancies and occurs by a variety of molecular mechanisms which probably reflect the existence of multiple factors responsible for its normal control. Here, I provide a detailed summary of recent progress and (...) current views on c‐myc gene regulation. (shrink)

El artículo aborda la refutación agustiniana del escepticismo, según se recoge en dos parábolas estudiadas con detalle en Contra Academicos. Señalando sus ideas y el influjo de Virgilio y Cicerón.

Recent data show that catastrophic events during one cell cycle can cause massive genome damage producing viable clones with unstable genomes. This is in contrast with the traditional view that tumorigenesis requires a long‐term process in which mutations gradually accumulate over decades. These sudden events are likely to result in a large increase in genomic diversity within a relatively short time, providing the opportunity for selective advantages to be gained by a subset of cells within a population. This genetic diversity (...) amplification, arising from a single aberrant cell cycle, may drive a population conversion from benign to malignant. However, there is likely a period of relative genome stability during the clonal expansion of tumors – this may provide an opportunity for therapeutic intervention, especially if mechanisms that limit tolerance of aneuploidy are exploited. (shrink)

Objectives: To analyse legislation and medical professional positions concerning the doctor’s role in assisted dying in western Europe, and to discuss their implications for doctors.Method: This paper is based on country-specific reports by experts from European countries where assisted dying is legalised , or openly practiced , or where it is illegal .Results: Laws on assisted dying in The Netherlands and Belgium are restricted to doctors. In principle, assisted suicide is not illegal in either Germany or Switzerland, but a doctor’s (...) participation in Germany would violate the code of professional medical conduct and might contravene of a doctor’s legal duty to save life. The Assisted Dying for the Terminally Ill Bill proposed in the UK in 2005 focused on doctors, whereas the Proposal on Assisted Dying of the Norwegian Penal Code Commission minority in 2002 did not.Professional medical organisations in all these countries except The Netherlands maintain the position that medical assistance in dying conflicts with the basic role of doctors. However, in Belgium and Switzerland, and for a time in the UK, these organisations dropped their opposition to new legislation. Today, they regard the issue as primarily a matter for society and politics. This “neutral” stance differs from the official position of the Royal Dutch Medical Association which has played a key role in developing the Dutch practice of euthanasia as a “medical end-of-life decision” since the 1970s.Conclusion: A society moving towards an open approach to assisted dying should carefully identify tasks to assign exclusively to medical doctors, and distinguish those possibly better performed by other professions. (shrink)

This book provides an overview of some of the most important critics of “Enlightenment rationalism.” The subjects of the volume—including, among others, Burke, Kierkegaard, Nietzsche, T.S. Eliot, Wittgenstein, Heidegger, C.S. Lewis, Gabriel Marcel, Russell Kirk, and Jane Jacobs—do not share a philosophical tradition as much as a skeptical disposition toward the notion, common among modern thinkers, that there is only one standard of rationality or reasonableness, and that that one standard is or ought to be taken from the presuppositions, methods, (...) and logic of the natural sciences. The essays on each thinker are intended not merely to offer a commentary on that thinker, but also to place that thinker in the context of this larger stream of anti-rationalist thought. Thus, while this volume is not a history of anti-rationalist thought, it may contain the intimations of such a history. (shrink)

The North American wood frog, Rana sylvatica, endures seasonal whole‐body freezing during the winter and thawing during the spring without sustaining any apparent damage from ice or oxidative stress. Strategies from these frogs may solve the shortage of human donor organs, which is a multidisciplinary problem that can be alleviated by eliminating geographical boundaries. Rana sylvatica deploys an array of molecular and physiological responses, such as glucose production and microRNA regulation, to help it survive the cold. These strategies have been (...) adapted in the lab to impart cryotolerance in liver cells, and the non‐freezing supercooled storage of transplantable rat livers − milestones that have advanced the field toward cryopreserving human donor organs in the clinic. In this review, a case is presented for the use of non‐coding RNAs to decrease oxidative damage of donor organs by activating endogenous antioxidant systems prior to procurement. (shrink)

This collection, the first of its kind, brings together specially commissioned academic essays to mark fifty years since the death of John Kennedy Toole.